Deciphering the mutational signatures by genetics, genomics and microfluidics

A 2-year post-doctoral position in genetics, genomics and microfluidics funded by a grant from ITMO Cancer (Aviesan, Inserm) is open in the group of Dr. Julie Soutourina at I2BC, CEA/Saclay (Paris region, France), in close collaboration with Dr. Florent Malloggi (LIONS, CEA/Saclay).
The post-doctoral fellow will participate in the interdisciplinary collaborative project to improve our understanding of the mutational processes at the origin of cancers. We aim in deciphering the impact of transcription and DNA repair combined with mutagen exposure on mutational processes in human cancers using a combination of genetic, genomic, microfluidic and computational approaches. We propose to take advantage of the yeast model to perform large-scale mutational experiments and to identify the most mutagenic combinations of genetic background and mutagen treatment that will be then directly tested in human cells. A novel methodological framework based on microfluidics, allowing to considerably accelerate mutation accumulation experiments in yeast by unprecedented parallelization that we recently developed, will be applied. A computational analysis of these experimental data will help to understand underlying mechanisms of mutational processes.
The successful candidate will have a PhD in molecular biology with solid knowledge in genetics and functional genomics. We are seeking for highly motivated candidates with a strong interest in the field of transcription and DNA repair in eukaryotes together with interdisciplinary approaches based on microfluidics. A previous experience on yeast model and DNA sequencing approaches will be important. Good communication skills in English or French are required.

Strain driven Group IV photonic devices: applications to light emission and detection

Straining the crystal lattice of a semiconductor is a very powerful tool enabling controlling many properties such as its emission wavelength, its mobility…Modulating and controlling the strain in a reversible fashion and in the multi% range is a forefront challenge. Strain amplification is a rather recent technique allowing accumulating very significant amounts of strain in a micronic constriction, such as a microbridge (up to 4.9% for Ge [1]), which deeply drives the electronic properties of the starting semiconductor. Nevertheless, the architectures of GeSn microlasers under strong deformation and recently demonstrated in the IRIG institute [2] cannot afford modulating on demand the applied strain and thus the emission wavelength within the very same device, the latter being frozen “by design”. The target of this 18 months post doc is to fabricate photonic devices of the MOEMS family (Micro-opto-electromechanical systems) combining the local strain amplification in the semiconductor and actuation features via an external stimulus, with the objectives to go towards: 1-a wide band wavelength tunable laser microsource and 2-new types of photodetectors, both in a Group IV technology (Si, Ge and Ge1-xSnx). The candidate will conduct several tasks at the crossroads between fabrication and optoelectronic characterization:
a-simulation of the mechanical operation of the expected devices using FEM softwares, and calculation of the electronic states of the strained semiconductor
b-fabrication of devices at the Plateforme Technologique Amont (lithography, dry etching, metallization, bonding), based on results of a
c-optical and material characterization of the fabricated devices (PL, photocurrent, microRaman, SEM…) at IRIG-PHELIQS and LETI.
A PhD in the field of semiconductors physics or photonics, as well as skills in microfabrication are required.

[1] A. Gassenq et al, Appl. Phys. Lett.108, 241902 (2016)
[2] J. Chrétien et al, ACS Photonics2019, 6, 10, 2462–2469

Modeling silicon and germanium spin qubits

Silicon/Germanium spin qubits have attracted increasing attention and have made outstanding progress in the past two years. In these devices, the elementary information is stored as a coherent superposition of the spin states of an electron in a Si/SiGe heterostructure, or of a hole in a Ge/SiGe heterostructure. These spins can be manipulated electrically owing to the intrinsic (or to a synthetic) spin-orbit coupling, and get entangled through exchange interactions, allowing for the implementation of a variety of one- and two-qubit gates required for quantum computing and simulation. The aims of this postdoctoral position are to strengthen our understanding and support the development of electron and hole spin qubits based on Si/Ge heterostructures through analytical modeling as well as advanced numerical simulation. Topics of interests include spin manipulation & readout, exchange interactions in 1D and 2D arrays, coherence and interactions with other quasiparticles such as photons. The selected candidate will join a lively project bringing together > 50 people with comprehensive expertise covering the design, fabrication, characterization and modeling of spin qubits. He/She is expected to start early 2023, for up to three years.

Post doctoral/Research engineer position in esophageal tissue engineering using bioprinting techniques

Due to disease such as cancer or accidents such as caustic burns, the esophagus is sometimes irreversibly damaged and the only option is to remove it and replace it by using the stomach and part of the digestive tract, which often leads to serious complications and even in the best cases to poor functional results and poor quality of life. The most advanced current developments in tissue engineering for the esophagus is the use of decellularized donor tissue and clinical trials are ongoing at St Louis Hospital in this area. This approach however still presents some limitations, in particular related to donor shortage and inflammatory response. In order to prepare the next generation approach, the lab initiated a project funded by MSD Avenir to build an esophagus substitute using 3D printing. This bottom-up approach which uses bioinks as a starting material allows full control over 3D architecture and the construct can be thus personalized to the patient’s morphology and pathology, including smaller sizes for pediatric patients, in unlimited supply which is a great advantage over donor tissue. We have patented a formulation based on both natural and synthetic polymers which shows similar mechanical properties when compared to native esophagi, good suturability as well as high porosity to allow cell colonization. It also presents slow degradation as the ultimate aim is that it be replaced with native regenerated tissue over time.

We are seeking a highly motivated and autonomous post-doctoral fellow or research engineer to continue this project and characterize long term culture on this scaffold by re-epithelializing the interior of the tube and seeding primary endothelial and muscular cells on the outer part. Characterizations will include both material mechanical testing and long term cell behavior, morphology and analysis of any toxicity.

Location; St Louis Hospital, Paris

Catalytic properties at the nanoscale probed by time-resolved Bragg coherent diffraction imaging

The postdoctoral research project is part of a five-year ERC-funded project called CARINE (Coherent diffrAction foR a Look Inside NanostructurEs towards atomic resolution: catalysis and interfaces – to develop and apply new coherent diffraction imaging (CDI) capabilities. The main objective of the project is to image nanostructures in situ during reaction and to reveal their structure evolution in time and at the nanoscale to probe bulk, surface and interface effects, as well as defects. Catalysts play a key role in approximatively 90% of industrial chemical processes. The development of heterogeneous catalysis with selectivity targeting the 100% is a constant challenge as well as understanding the durability and ageing of the catalyst itself. However, the catalytic process and the associated structural changes still remain poorly understood. Understanding how catalyst structure is affected by the adsorbed layer under reaction conditions is therefore of utmost importance to formulate catalyst structure-performance relations that guide the design of better catalysts.

Postdoctoral position on the modeling of silicon spin qubits

A post-doctoral position is opened at the Interdisciplinary Research Institute of Grenoble (IRIG) of the CEA Grenoble (France) on the theory and modeling of silicon spin quantum bits (qubits). The selected candidate is expected to start at the beginning of year 2022, for up to two years.
Quantum information technologies on silicon have raised an increasing interest over the last few years. Grenoble is pushing forward an original platform based on the “silicon-on-insulator” (SOI) technology. In order to meet the challenges of quantum information technologies, is essential to support the experimental activity with state-of-the-art modeling. For that purpose, CEA is actively developing the “TB_Sim” code. TB_Sim is able to describe very realistic qubit structures down to the atomic scale when needed using atomistic tight-binding and multi-bands k.p models for the electronic structure of the materials. The aims of this postdoctoral position are to strengthen our understanding of spin qubits, and to progress in the design of efficient and reliable Si and Si/Ge spin qubit devices and arrays using a combination of analytical models and advanced numerical simulations with TB_Sim. Topics of interest include spin manipulation & readout in electron and hole qubits, exchange interactions in 1D and 2D arrays of qubits and operation of multi-qubit gates, sensitivity to noise (decoherence) and disorder (variability). This work takes place in the context of the EU QLSI project and will be strongly coupled to the experimental activity in Grenoble and among the partners of CEA in Europe.

Artificial Intelligence applied to Ion Beam Analysis

A one year contract postdoctoral research position is open at the laboratory for light element studies (LEEL, CEA/DRF) and the Data Science for Decision Laboratory (LS2D, DRT/LIST) and focuses on data processing based on AI and machine learning, here in the scope of Ion Beam Analysis (IBA).
In the context of this project, the successful candidate will have to fulfill the following tasks:
1- Design of a multispectral dictionary.
2- Learning module development.
3- Main code programming.
4- Development of a module dedicated to multispectral mappings.
5- Benchmarking.
The postdoctoral research associate will be hosted and supervised within LEEL and LS2D.

Modeling silicon-on-insulator quantum bit arrays

A post-doctoral position is open at the Interdisciplinary Research Institute of Grenoble (IRIG, formerly INAC) of the CEA Grenoble (France) on the theory and modeling of arrays of silicon-on-insulator quantum bits (SOI qubits). This position fits into an ERC Synergy project, quCube, aimed at developing two-dimensional arrays of such qubits. The selected candidate is expected to start between October and December 2019, for up to three years.
Many aspects of the physics of silicon qubits are still poorly understood, so that it is essential to support the experimental activity with state-of-the-art modeling. For that purpose, CEA is actively developing the “TB_Sim” code. TB_Sim relies on atomistic tight-binding and multi-bands k.p descriptions of the electronic structure of materials and includes, in particular, a time-dependent configuration interaction solver for the dynamics of interacting qubits.
The aims of this post-doctoral position are to improve our understanding of the physics of these devices and optimize their design, and, in particular,
- to model spin manipulation, readout, and coherence in one- and two-dimensional arrays of SOI qubits.
- to model exchange interactions in these arrays and assess the operation of multi-qubit gates.
The candidate will have the opportunity to interact with the experimental teams from CEA/IRIG, CEA/LETI and CNRS/Néel involved in quCube, and will have access to data on state-of-the-art devices.

Leaching foams to extract metals from electronic waste

The subject is part of the ANR "Foamex" project covering TRL from 1 to 5 and focussing on the development of recycling of some metals from a shred of electronic cards, this recycling being carried out in a fluid foam (minimization of the volume of solvents) that can be considered at the first level as a dynamic chromatography column. The principle is to use the foam as a reservoir containing an acid solution and specific oxidizing agents to dissolve and extract metals in the form of ionic species, a phenomenon enhanced by friction between bubbles and simultaneously to concentrate them via the fluid and mobile liquid/air interfaces by flow.

Nanofabrication of spintronic spiking neurons

In the frame of the French national ANR project SpinSpike, Spintec laboratory is opening a postdoctoral researcher position. The candidate will work in collaboration with UMPhy CNRS-Thales and Thales TRT. The objective is the realization of proof-of-concept magnetic tunnel junction based artificial spiking neurons able to generate spikes and propagate them between coupled artificial neurons.
The candidate should have a strong background in nanofabrication and should be familiar with common techniques of optical and e-beam lithography as well as different etching techniques. The candidate can also be involved in the electrical characterization of the devices.
The position is expected to start on April 1, 2021 and go on for up to 2 years jointly between the RF team and MRAM teams of Spintec. The contract will be managed by CEA and funded by ANR Agency.
We offer an international and competitive environment, state-of-the-art equipment, and the possibility to perform research at the highest level. We promote teamwork in a diverse and inclusive environment and welcome all kinds of applicants. Further information about Spintec laboratory .