Investigation of Lanthanide Salt Interactions with Lipid Systems

Lanthanide–lipid interactions have gained significant attention due to their importance in biophysical and technological applications, including magnetic resonance imaging, fluorescence-based cell labelling and drug delivery. This project aims to investigate the interactions between different lanthanide salts (LnX3, where X = Cl?, ClO4?, NO3?, etc.) and lipid aggregates, focusing on the precipitation and gelation phenomena that occur when their concentration exceeds a certain threshold. Understanding these phenomena is essential for studying self-assembly and phase behaviour in soft matter systems. By examining how lanthanide ions interact with lipid aggregates—particularly in the presence of different anions—this study seeks to elucidate their roles in inducing precipitation and gelation. To this end, a combination of spectroscopic, scattering, microscopy, and rheological techniques will be employed to characterize the molecular interactions in lanthanide–phospholipid systems. These investigations will provide insights into the structural and dynamic properties of such systems and support their application in both biophysical and technological contexts.

Lightweight and high-strength metamaterials with innovative architectures manufactured by additive manufacturing for constrained environments

Environmental constraints, rising raw material costs, and the need to reduce carbon footprints drive the development of more porous materials that combine lightness with mechanical strength. Such materials meet the requirements of strategic sectors including aerospace, space, transportation, energy, and high-performance physics instruments.

Mechanical metamaterials, composed of micro-lattice structures produced by 3D printing, offer a unique potential to address these challenges. By tailoring the topology of their internal networks, it becomes possible to achieve stiffness-to-density ratios higher than those of conventional materials and to adapt their architecture to target specific mechanical or functional properties.

This thesis is part of this wave of innovation. It aims to develop ultralight metallic metamaterials whose architecture is optimized to maximize mechanical performance while maintaining isotropy, ensuring predictable behavior using conventional engineering tools, including finite element analysis, numerical simulation, and multiscale approaches. The research builds on the recognized expertise of the CEA, particularly at IRAMIS and IRFU/DIS, in designing isotropic random metastructures and shaping them through metal additive manufacturing.

By combining numerical mechanics, advanced design, multi-process additive manufacturing, and in situ characterization, this thesis seeks to push the current limits of design and fabrication of complex metallic structures.

Unveiling the Universal Coupling Between Accretion and Ejection: From Microquasars to Extragalactic Transients

This PhD project investigates the universal coupling between accretion and ejection, the fundamental processes through which black holes and neutron stars grow and release energy. Using microquasars as nearby laboratories, the project will study how variations in accretion flows produce relativistic jets, and how these mechanisms scale up to supermassive black holes in tidal disruption events (TDEs).

Accretion–ejection coupling drives energy feedback that shapes galaxy formation and evolution, yet its physical origin remains poorly understood. The candidate will combine multi-wavelength observations—from SVOM (X-ray/optical) and new radio facilities (MeerKAT, SKA precursors)—to perform time-resolved analyses linking accretion states to jet emission.
Recent missions such as Einstein Probe and the Vera Rubin Observatory (LSST) will greatly expand the sample of transients, including jetted TDEs, enabling new tests of jet-launching physics across mass and time scales.

Working within the CEA/IRFU team, a major SVOM partner, the student will participate in real-time transient detection and multi-wavelength follow-up, while also exploiting archival data to provide long-term context. This project will train the candidate in high-energy astrophysics, radio astronomy, and data-driven discovery, contributing to a unified understanding of accretion, jet formation, and cosmic feedback.

Explainable AI for interpretation of Small Angle Scattering

The PhD will be conducted in two laboratories at Paris-Saclay: one group with expertise in artificial intelligence developed over many years, MIA-PS (INRAE), and another in the physics of matter – soft matter, biology – MMB-LLB (CEA/CNRS).
Small-Angle Scattering techniques (X-rays, neutrons, light) involve a constantly growing community, particularly active in France, especially in soft matter and biology. The transition of data from reciprocal space to real space is achieved via different models – in which the MMB group is an expert – whether concerning shape – sphere, rod, platelet, polymer chain – or interactions – attraction, aggregation, repulsion, arrangement. Furthermore, more complex structures, such as proteins or irregular aggregates, require computational or empirical approaches. In all cases, the results are not unequivocal. This is particularly challenging for research groups new to the technique.
In this thesis, thanks to MIA-PS's expertise in AI (machine learning, optimization, visualization), the focus will be on developing explainable AI methods. Part of the modeling involves explained mathematical and physical models, while another part relies on so-called "black box" models, which will be progressively explained. The doctoral candidate will have access to data from three use cases provided by the LLB, and to their experts, to develop a generic methodology. A first step could be based on the globally shared software SasView, a treasure trove of explicit models. We have already received a positive response from the SasView developers, which could therefore serve as a dissemination tool. A valuable contribution will be the access to complementary DPA measurements via the LLB platforms and the SOLEIL and ESRF synchrotrons.
Subsequently, a component focusing on human-computer interaction—ensuring that users remain fully responsible for constructing a physico-chemical-biological explanation—can be implemented. MIA-PS is also an expert in advanced interactive visualization methods.

This project therefore combines highly advanced developments in computer science with a wealth of real-world systems chosen for their originality and, of course, their potential applications.

Magnetar formation: from amplification to relaxation of the most extreme magnetic fields

Magnetars are neutron stars with the strongest magnetic fields known in the Universe, observed as high-energy galactic sources. The formation of these objects is one of the most studied scenarios to explain some of the most violent explosions: superluminous supernovae, hypernovae, and gamma-ray bursts. In recent years, our team has succeeded in numerically reproducing magnetic fields of magnetar-like intensities by simulating dynamo amplification mechanisms that develop in the proto-neutron star during the first seconds after the collapse of the progenitor core. However, most observational manifestations of magnetars require the magnetic field to survive over much longer timescales (from a few weeks for super-luminous supernovae to thousands of years for Galactic magnetars). This thesis will consist of developing 3D numerical simulations of magnetic field relaxation initialized from different dynamo states previously calculated by the team, extending them to later stages after the birth of the neutron star when the dynamo is no longer active. The student will thus determine how the turbulent magnetic field generated in the first few seconds will evolve to eventually reach a stable equilibrium state, whose topology will be characterized and compared with observations.

Study of the rare earth elements selective detection in Pseudomonas putida and development of chelating architectures

Rare earths (REE) are widely used in high technology, and demand for REE is set to double over the next 30 years. The selective extraction and recycling of REE has a triple challenge: economic, technological and ecological. Currently, less than 1% of REEs are recycled. What's more, extraction methods are tedious and polluting. They require several stages with acids or solvents. The discovery in 2011 of enzymes that naturally use light REE has opened up new prospects. The development of biosourced methods could be a key element in unlocking current selectivity and extraction barriers. This thesis is part of the biotechnologies of tomorrow theme. The aim of this thesis is to acquire fundamental data on the molecular mechanism of a biological system for selective TR perception in order to take advantage of it for the development of selective chelating architectures. To do this, a screen based on the use of fluorescent reporters that respond specifically to certain TRs will be used. Cell biology, biochemistry, and in silico analysis techniques using artificial intelligence tools will be used to accomplish this project. The results obtained will identify: 1) the molecular mechanism of TR detection, 2) the factors influencing selectivity, and 3) the development of selective chelating architectures based on 1) and 2).

Exoplanets: phase curves observed by JWST

The James Webb Space Telescope (JWST), launched by NASA on December 25, 2021, is revolutionizing our understanding of the cosmos, particularly in the field of exoplanets. With more than 6,000 exoplanets detected, a great variety of worlds have been discovered, some with no equivalent in our Solar System, such as « hot Jupiters » or « super-Earths ». JWST now enables detailed characterization of exoplanetary atmospheres thanks to its spectroscopic instruments covering wavelengths from 0.6 to 27 µm and its large light-collecting area (25 m²). This capability allows determination of molecular composition, the presence of clouds or aerosols, the pressure–temperature profile, and the physical and chemical processes at work in these atmospheres.

The main method used is the so-called transit method, which observes variations in brightness when a planet passes in front of or behind its star (secondary eclipse). Nevertheless, observations over the entire orbital period (phase curve)—which also includes a transit and two eclipses—provide even more information. With phase curves, the energy budget, longitudinal structure, and atmospheric circulation can be directly observed. JWST has already obtained phase-curve data of exceptional quality. Many of these datasets are now publicly available and contain a wealth of information, though they are only partially exploited. The length of these observations, the extremely faint signals (a few tens of ppm), and the presence of subtler instrumental effects make the analysis of these data more complex.

The proposed PhD will first focus on studying and correcting these instrumental effects, then on extracting atmospheric properties using the TauREx software (https://taurex.space/), under the co-supervision of Quentin Changeat (University of Groningen) and Pierre-Olivier Langage (CEA Paris-Saclay). This PhD will contribute to preparing the scientific exploitation of the ESA Ariel mission (launch planned for 2031), entirely dedicated to the study of exoplanetary atmospheres and expected to observe nearly 50 phase-curves.

Understanding the signals emitted by moving liquids

Elasticity is one of the oldest physical properties of condensed matter. It is expressed by a constant of proportionality G between the applied stress (s) and the deformation (?): s = G.? (Hooke's law). The absence of resistance to shear deformation (G' = 0) indicates liquid-like behavior (Maxwell model). Long considered specific to solids, shear elasticity has recently been identified in liquids at the submillimeter scale [1].
The identification of liquid shear elasticity (non-zero G') is a promise of discoveries of new liquid properties. For example, do we know that a confined liquid changes temperature under flow? Yet no classical model (Poiseuille, Navier-Stokes, Maxwell) predicts the effect because without long-range correlation between molecules (i.e. without elasticity), the flow is dissipative, therefore athermal. For a change in temperature to be flow induced (without a heat source), the liquid must have elasticity and this elasticity must be stressed [1,2].
The PhD thesis will explore how the mechanical energy of the flow is converted in a thermal response [2]. We will exploit the capacity of conversion to develop a new generation of microfluidic devices (patent FR2206312).
We will also explore the impact of the wetting on the liquid flow, and reciprocally, we will examine how the liquid flow modifies the solid dynamics (THz) of the substrate [3]. Powerful methods only available in Very Large Research Facilities such as the ILL will be used to probe the non-equilibrium state of solid phonons. Finally, we will strengthen our existing collaborations with theoreticians.

The PhD topic is related to wetting, macroscopic thermal effects, phonon dynamics and liquid transport.

1. A. Zaccone, K. Trachenko, “Explaining the low-frequency shear elasticity of confined liquids" PNAS, 117 (2020) 19653–19655. Doi:10.1073/pnas.2010787117
2. E. Kume, P. Baroni, L. Noirez, “Strain-induced violation of temperature uniformity in mesoscale liquids” Sci. Rep. 10 13340 (2020). Doi : 10.1038/s41598-020-69404-1.
3. M. Warburton, J. Ablett, P. Baroni, JP Rueff, L. Paolasini, L. Noirez, “Identification by Inelastic X-Ray scattering of bulk alteration of solid dynamics due to Liquid Wetting”, J. of Molecular Liquids 391 (2023) 123342202

Magneto-convection of solar-type stars: flux emergence and origin of starspots

The Sun and solar-type stars possess rich and variable magnetism. In our recent work on turbulent convective dynamos in this type of star, we have been able to highlight a magneto-rotational history of their secular evolution. Stars are born active with short magnetic cycles, then slow down due to braking by their magnetized particle wind, their magnetic cycle lengthens to become commensurate with that of the Sun (lasting 11 years) and finally, for stars that live long enough, they end up with a loss of cycle and a so-called anti-solar rotation (slow equator/fast poles). The agreement with observations is excellent, but we are missing an essential element to conclude: What role do sunspots/starspots play in the organization of the magnetism of these stars, and are they necessary for the appearance of a stellar magnetic cycle, e.g. the so-called “paradox of spotty dynamos”? Indeed, our HPC simulations of solar dynamos do not have yet the angular resolution to resolve the spots, and yet we do observe cycles in our simulations of stellar dynamos for Rossby numbers < 1. So, are the spots simply a surface manifestation of an internal self-organization of the cyclic magnetism of these stars, or do they play a decisive role? Furthermore, how do the latitudinal flux emergence and the size and intensity of the spots forming on the surface evolve during the magneto-rotational evolution of these stars? To answer these key questions in stellar and solar magnetism in support of the ESA space missions Solar Orbiter and PLATO, in which we are involved, new HPC simulations of stellar dynamos must be developed, allowing us to get closer to the surface and thus better describe the process of magnetic flux emergence and the possible formation of sun/starspots. Recent tests showing that magnetic concentrations inhibiting local surface convection form in simulations with a higher magnetic Reynolds number and smaller-scale surface convection strongly encourage us to continue this project beyond the ERC Whole Sun project (ending in April 2026). Thanks to the Dyablo-Whole Sun code that we are co-developing with IRFU/Dedip, we wish to study in detail the convective dynamo, the emergence of magnetic flux, and the self-consistent formation of resolved spots, using its adaptive mesh refinement capability while varying global stellar parameters such as rotation rate, convective zone thickness, and surface convection intensity to assess how their number, morphology and latitude of emergence change and if they contribute or not to the closing of the cyclic dynamo loop.

Study of heavy nuclei: from the mass measurement to the spectroscopy of Americium nuclei and commissioning of the double Penning trap PIPERADE

The atomic nucleus is a complex system that continues to be actively studied more than a century after its discovery. Among the open questions, the question of the limits of existence of the nucleus remains central: what are the numbers of protons and neutrons that allow a bound nucleus to form? This question can be addressed using mass measurements that provide access to the binding energy of the nucleus, one of its most fundamental properties. The objective of this thesis is, on the one hand, to perform high-precision mass measurements of the isotopes 234-238Am (Z = 95) isotopes at the University of Jyväskylä, Finland (experiment planned in 2026), and, on the other hand, to participate in the installation and commissioning of the PIPERADE double Penning trap (PIèges de PEnning pour les RAdionucléides à DESIR) at GANIL in Caen.
The americium nuclei that will be studied in this thesis are at the boundary between two regions of particular interest: the octupole deformation region (pear-shaped nuclei) and the fission isomer region (meta-stable states of nuclei decaying by fission), and measuring their mass will provide a better understanding of the properties of these exotic nuclei.
PIPERADE is a device that can be used to perform high-precision mass measurements. Currently in the characterisation phase in Bordeaux, its installation at GANIL will enable the study of a wide range of exotic nuclei by measuring their mass. Currently undergoing characterisation in Bordeaux, its installation at GANIL (planned for 2027) will enable the study of a wide range of exotic nuclei by measuring their mass, but also by using separation techniques to purify the radioactive beams before sending them to other experimental devices.

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