The LANIE laboratory is focused on downscaling the sample purification steps performed by solid-phase extraction chromatography. The strategy is based on the implantation of functionalized polymeric monoliths within the channels of microsystems made of cyclic olefin copolymer (COC), material known to be easy to process but chemically inert. Once this key step is validated, this project aims to set up a comprehensive analytical pipeline in the laboratory, starting from the design, prototyping, and manufacturing of integrated miniaturized extraction devices, up to their de facto implementation for the reduced-scale analysis of U- and Pu- based samples.