CEA-Leti is looking for a high-level junior principal investigator to design a closed-loop brain implant based on semi-quantitative measurements of local biomarker(s). Those measurements aim at controlling the treatment – should it be photobiomodulation or local drug delivery- in a closed-loop fashion, with the ambitious goal to go towards a real time, self-adapted process. The targeted brain disorders are Parkinson disease and Drug Resistant Epilepsy (DRE). Therefore, candidates should have expertise in neuroscience and neuromodulation technology but also in engineering. Before identifying the technologies to address the design a closed-loop implant, the candidate will accurately define the clinical need and constraints for Parkinson’s disease and DRE, in terms of pertinent and measurable biomarkers, brain-regions to access to, implantability, etc
Those specifications will be the basis to initiate developments using technologies available at, but no limited to, CEA-Leti, including miniaturized optical (infrared & visible) and electrochemical probes that will trigger the drug control loop. The successful candidate must be able to carry out the work program by her/himself, but will rely on the experience in neuroscience, preclinical, clinical, opto-and microelectronics research of the institute. She/he also shall bring innovative ideas and pre-sent high capabilities at working in a multidisciplinary teams issued from different departments of CEA-Leti. Recent advances in biocompatible, miniature electronics inside LETI can be extrapolated to specific neuromonitoring needs in neurodegenerative diseases and DRE. Indeed, off-the-shelf technologies exist at LETI that could be transferred and adapted to implantable devices.