Advanced reconstruction methods for cryo-electron tomography of biological samples
Cryo-electron tomography (CET) is a powerful technique for the 3D structural analysis of biological samples in their near-native state. CET has seen remarkable advances in instrumentation in the last decade but the classical weighted back-projection (WBP) remains by far the standard CET reconstruction method. Due to radiation damage and the limited tilt range within the microscope, WBP reconstructions suffer from low contrast and elongation artifacts, known as ‘missing wedge’ (MW) artifacts. Recently, there has been a revival of interest in iterative approaches to improve the quality and hence the interpretability of the CET data.
In this project, we propose to go beyond the state-of-the-art in CET by (1) applying curvelet- and shearlet-based compressed sensing (CS) algorithms, and (2) exploring deep learning (DL) strategies with the aim to denoise et correct for the MW artifacts. These approaches have the potential to improve the resolution of the CET reconstructions and facilitate the segmentation and sub-tomogram averaging tasks.
The candidate will conduct a comparative study of iterative algorithms used in life science, and CS and DL approaches optimized in this project for thin curved structures.
Simulation of thermal transport at sub-Kelvin
Thermal management in quantum computers is an urgent and crucial task. As the number of qubits rapidly scales, more electric circuits are placed close to qubits to operate them. Joule-heating of these circuits could significantly warm the qubit device, degrading its fidelity. With intensive activity in quantum computing at Grenoble, we (CEA-LETI, Grenoble, France) are looking for an enthusiastic post-doc researcher to study thermal transport at cryogenic temperature (sub-Kelvin).
The post-doc will apply the finite-element non-equilibrium Green’s function [1], developed in the group of Natalio Mingo at CEA-Grenoble, to simulate phonon transport in various designed structures. The simulation result promotes comparison with on-going experiments and constructive discussions in order to optimize the thermal management.
[1] C. A. Polanco, A. van Roekeghem, B. Brisuda, L. Saminadayar, O. Bourgeois, and N. Mingo, Science Advances 9, 7439 (2023).
Exploring microfluidic solutions for manufacturing targets for fusion power generation
As part of a call for projects on "innovative nuclear reactors", the TARANIS project involves studying the possibility of energy production by a power laser-initiated inertial confinement fusion power plant. The current context, which encourages the development of low-carbon energies, and the fusion experiments carried out by the NIF's American teams, make it very attractive to conduct high-level research aimed at eventually producing an economically attractive energy source based on inertial fusion.
Among the many technical hurdles to be overcome, the production of fusion targets with a suitable reaction scheme compatible with energy production is a major challenge. The CEA has the know-how to produce batches of capsules containing the fusible elements of the reaction. However, the current process is not suitable for mass production of hundreds of thousands of capsules per day at an acceptable cost.
One high-potential avenue lies in the use of microfluidic devices, for which the Microfluidic Systems and Bioengineering Laboratory (LSMB) of the Health Technologies and Innovation Department (DTIS) of CEA's DRT has recognized expertise.
Development of noise-based artifical intellgence approaches
Current approaches to AI are largely based on extensive vector-matrix multiplication. In this postdoctoral project we would like to pose the question, what comes next? Specifically we would like to study whether (stochastic) noise could be the computational primitive that the a new generation of AI is built upon. This question will be answered in two steps. First, we will explore theories regarding the computational role of microscopic and system-level noise in neuroscience as well as how noise is increasingly leveraged in machine leaning and artificial intelligence. We aim to establish concrete links between these two fields and, in particular, we will explore the relationship between noise and uncertainty quantification.
Building on this, the postdoctoral researcher will then develop new models that leverage noise to carry out cognitive tasks, of which uncertainty is an intrinsic component. This will not only serve as an AI approach, but should also serve as a computational tool to study cognition in humans and also as a model for specific brain areas known to participate in different aspects of cognition, from perception to learning to decision making and uncertainty quantification.
Perspectives of the postdoctoral project should inform how future fMRI imaging and invasive and non-invasive electrophysiological recordings may be used to test theories of this model. Additionally, the candidate will be expected to interact with other activates in the CEA related to the development of noise-based analogue AI accelerators.
Study of the specific features of highly distributed architectures for decision and control requirements
Our electricity infrastructure has undergone and will continue to undergo profound changes in the coming decades. The rapid growth in the share of renewables in electricity generation requires solutions to secure energy systems, especially with regard to the variability, stability and balancing aspects of the electricity system and the protection of the grid infrastructure itself. The purpose of this study is to help design new decision-making methods, specially adapted to highly distributed control architectures for energy networks. These new methods will have to be evaluated in terms of performance, resilience, robustness and tested in the presence of various hazards and even byzantines.
LLMs hybridation for requirements engineering
Developing physical or digital systems is a complex process involving both technical and human challenges. The first step is to give shape to ideas by drafting specifications for the system to be. Usually written in natural language by business analysts, these documents are the cornerstones that bind all stakeholders together for the duration of the project, making it easier to share and understand what needs to be done. Requirements engineering proposes various techniques (reviews, modeling, formalization, etc.) to regulate this process and improve the quality (consistency, completeness, etc.) of the produced requirements, with the aim of detecting and correcting defects even before the system is implemented.
In the field of requirements engineering, the recent arrival of very large model neural networks (LLMs) has the potential to be a "game changer" [4]. We propose to support the work of the functional analyst with a tool that facilitates and makes reliable the writing of the requirements corpus. The tool will make use of a conversational agent of the transformer/LLM type (such as ChatGPT or Lama) combined with rigorous analysis and assistance methods. It will propose options for rewriting requirements in a format compatible with INCOSE or EARS standards, analyze the results produced by the LLM, and provide a requirements quality audit.
Development of piezoelectric resonators for power conversion
CEA-Leti has been working to improve energy conversion technologies for over 10 years. Our research focuses on designing more efficient and compact converters by leveraging GaN-based transistors, thereby setting new standards in terms of ultra-fast switching and energy loss reduction.
In the pursuit of continuous innovation, we are exploring innovative paths, including the integration of piezoelectric mechanical resonators. These emerging devices, capable of storing energy in the form of mechanical deformations, offer a promising perspective for increased energy density, particularly at high frequencies (>1 MHz). However, the presence of parasitic resonance modes impacts the overall efficiency of the system. Therefore, we are in need of an individual with skills in mechanics, especially in vibrational mechanics, to enhance these cleanroom-manufactured micromechanical resonators.
You will be welcomed in Grenoble within a team of engineers, researchers and doctoral students, dedicated to innovation for energy, which combines the skills of microelectronics and power systems from two CEA institutes, LETI and LITEN, close to the needs of the industry (http://www.leti-cea.fr/cea-tech/leti/Pages/recherche-appliquee/plateformes/electronique-puissance.aspx).
If you are a scientifically inclined mind, eager to tackle complex challenges, passionate about seeking innovative solutions, and ready to contribute at the forefront of technology, this position/project represents a unique opportunity. Join our team to help us push the boundaries of energy conversion.
References : http://scholar.google.fr/citations?hl=fr&user=s3xrrcgAAAAJ&view_op=list_works&sortby=pubdate
Modeling of charge noise in spin qubits
Thanks to strong partnerships between several research institutes, Grenoble is a pioneer in the development of future technologies based on spin qubits using manufacturing processes identical to those used in the silicon microelectronics industry. The spin of a qubit is often manipulated with alternating electrical (AC) signals through various spin-orbit coupling (SOC) mechanisms that couple it to electric fields. This also makes it sensitive to fluctuations in the qubit's electrical environment, which can lead to large qubit-to-qubit variability and charge noise. The charge noise in the spin qubit devices potentially comes from charging/discharging events within amorphous and defective materials (SiO2, Si3N4, etc.) and device interfaces. The objective of this postdoc is to improve the understanding of charge noise in spin qubit devices through simulations at different scales. This research work will be carried out using an ab initio type method and also through the use of the TB_Sim code, developed within the CEA-IRIG institute. This last one is able of describing very realistic qubit structures using strong atomic and multi-band k.p binding models.
Calibration of the high dose rate flash therapy beam monitor of the IRAMIS facility
Ultra-flash beams are pulsed beams of high-energy electrons (over a hundred MeV) with pulse durations in the femto-second range. The IRAMIS facility (CEA Saclay) uses laser acceleration to produce this type of beam, with a view to their application in radiotherapy. The LNHB is in charge of establishing dosimetric traceability for the IRAMIS facility, and to do this it has to calibrate the facility's monitor. Current radiotherapy facilities are based on medical linear accelerators operating at energies of up to 18 MeV in electron mode. LNHB has such equipment. It is used to establish national references in terms of absorbed dose to water, under the conditions of the IAEA protocol TRS 398.
Establishing dosimetric traceability involves choosing the measurement conditions, knowing the transfer dosimeter characteristics used and any corrections to be applied to the measurements taking into account the differences between the IRAMIS Facility and those of LNHB.
Optimization of a metrological approach to radionuclide identification based on spectral unmixing
The Laboratoire national Henri Becquerel (LNE-LNHB) at CEA/Saclay is the laboratory responsible for French references in the field of ionizing radiations. For several years now, it has been involved in the development of an automatic analysis tool for low-statistics gamma spectra, based on the spectral unmixing technique. This approach makes it possible to respond to metrological constraints such as robust decision-making and unbiased estimation of counts associated with identified radionuclides. To extend this technique to field measurements, and in particular to the deformation of spectra due to interactions in the environment of a radioactive source, a hybrid spectral unmixing model combining statistical and automatic learning methods is currently being developed. The aim of this mathematical solution is to implement a joint estimation of the spectra measured and the counts associated with the radionuclides identified. The next step will be to quantify the uncertainties of the quantities estimated from the hybrid model. The aim is also to investigate the technique of spectral unmixing in the case of neutron detection with a NaIL detector. The future candidate will contribute to these various studies in collaboration with the Laboratoire d'ingénierie logicielle pour les applications scientifiques (CEA/DRF).