Imagerie de la compartimentation et de la pharmacologie du lithium par IRM du Lithium-7 in vivo at très haut champ magnétique.

At ultra-high magnetic field, increased polarization opens the way for the NMR imaging and spectroscopy of exotic nuclei such as Lithium-7 (7Li) and Sodium-23 (23Na) with unprecedented sensitivities.
During this PhD thesis, the goal will be to develop, validate and apply 23Na and 7Li preclinical imaging protocols in the context of the new 11.7T Iseult MRI scanner of NeuroSpin (CEA/DRF/JOLIOT) as well as on its 17.2 T preclinical scanner. The PhD student will continue the work realized these last years on 23Na and 7Li imaging and will push for better and more significant NRM data. Our focus will be to use these methods to study the pharmacology and biophysical properties of Lithium in the brain. In particular, we aim at investigating the transport kinetics of Li+ through the Blood-Brain-Barrier, its compartmentation and its competition with Na+ ions.