Background: This project follows a work supported by the Foundation for Medical Research (2018-2022) where we showed the relevance

of modifying the surface of platinum coils (intracranial implants used to treat aneurysms) in order to accelerate aneurysmal healing. This

was demonstrated in vivo by covalent grafting of a polysaccharide, fucoidane, on the surface of the coils.

Objectives of the thesis

The objectives of the thesis project are the following:

1- Optimize the coating of coils allowing a development under GMP (Good Manufacturing Practices) conditions and adapt the method to

an industrial process.

2- To fully characterize the coating in terms of density, thickness and regularity using physicochemical techniques (ATG, DSC, contact

angle, elemental analysis) and optical imaging (biphotonic imaging, scanning electron microscopy, AFM) and spectroscopic techniques

(EDS, XPS).

3- To validate the conditions retained by implantation of the modified coils in a rabbit aneurysmal model.

Partners: UMR NIMBE LICSEN, BALT Company, LVTS Inserm U1148 and XLIM UMR CNRS 7252, CHU Limoges.