The project aims at evaluating the efficacy of molecules combined with radiotherapy, in in vitro and in vivo models of breast cancer.
On the one hand, the student will evaluate the radioenhancer effect of bimetallic nanoparticles designed in the laboratory, on a murine model mainly. A clinical, histological, and immune monitoring will confirm the added value of such molecules for combination with radiotherapy. In addition, those innovative nanoparticles have been designed as biodosimeters, using unique physical properties of metallic nanoparticles. Therefore the project includes an evalution of the biodosimetry potential, in collaboration with physicists from CEA, who developed detection tools.
On the other hand, specific inhibitors for DNA repair will be used to block radiation-triggered repair. Thus, damaged cancer cells will be oriented towrads cell death, even in the case of radioresistant cells. The objective of the PhD program is to evaluate these molecules effect on in vitro cellular models, as well as on murine models of breast cancer.
Overall, the research project will benefit from the laboratorys’ collaborations with physicists and chemists, as well as the platforms of IRCM (irradiation, animal experimentation, microscopy, cytometry, etc...)