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Thesis
Home   /   Thesis   /   Energy efficiency for biochemical processes – Study of the cross-linking between biocatalyst immobilization and structured milli-reactor for enzymatic flow biocatalysis

Energy efficiency for biochemical processes – Study of the cross-linking between biocatalyst immobilization and structured milli-reactor for enzymatic flow biocatalysis

Abstract

In the current context of technological, energy and ecological transition, there is an urgent need to develop more sustainable and cost effective synthetic processes: flow biocatalysis, combination of biocatalysis and continuous flow chemistry, has emerged as a winning combination. It allows significant decrease in production steps, reduced energy use, higher flexibility and higher productivity. To address new industrial applications such as pharmaceuticals, the objective of this work is to propose a new biocatalytic production way based on flow chemistry and biocatalyst immobilization and to improve the cross-linking between process intensification and biocatalyst implementation. The ambition is to transpose enzymatic batch reactions towards continuous and sustainable processes. Three CEA departments are involved in this study, the Genoscope (Environmental Genomics and Metabolic Exploration, Evry), the Leti/DTBS (Health and Biology technologies Department, Grenoble) and the Liten/DTCH (Thermal, Conversion and Hydrogen Department, Grenoble). The PhD student will work on the definition, design, CFD modelling and experimental testing of a milli-structured reactor; on the elaboration of biocatalyst immobilization strategies and on the reactor scale-up to achieve flow productivity representative of industrial capacity.

Laboratory

Département Thermique Conversion et Hydrogène (LITEN)
Service Système Energétique Territoire et Industrie
Laboratoire des composants et systèmes thermiques
Paris-Saclay
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