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Thesis
Home   /   Thesis   /   Impact of pigment particles on the functions of macrophages

Impact of pigment particles on the functions of macrophages

Abstract

One French adult out of 7 is tattooed, this proportion increasing to

nearly one out of 4 among young adults (<35 years). Technically, a

tattoo represents the intradermal injection of pigments that are

resistant to degradation and therefore remain in place for life. If the

acute effects of tattooing (e.g. local inflammation) are well described,

the possible long-term effects are poorly known. The recent evolutions

in terms of population diversity, tattooed surface and diversity of

pigments used make difficult the extrapolations from retrospective

studies and desirable prospective studies on potential long-term effects

of tattoos. We therefore propose in this thesis to study the effects on

macrophages of the main pigments used for tattoos and in particular

those containing metals, metal oxides or organometallic components such

as copper phthalocyanines. To do so, we propose to combine

broad-spectrum (proteomic analysis) and targeted approaches, using

advanced culture systems that allow to study the persistence of

functional effects on macrophages. This work has a strong potential

societal impact.

The team has the necessary human resources to supervise the PhD student,

who will be supervised by Thierry Rabilloud, DR1 CNRS, and by Bastien

Dalzon, IR CNRS recently recruited to the laboratory. We have already

carried out preliminary tests which have shown that dyes such as zinc

white and cobalt violet have significant effects on macrophages, which

confirms us in the chances of success of this PhD program.

Laboratory

Institut de Recherche Interdisciplinaire de Grenoble
DIESE
Chimie et Biologie des Métaux
Université Grenoble Alpes
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