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Thesis
Home   /   Thesis   /   Multimodal approaches using Raman imaging to characterize microplastics and nanoplastics in cells and organisms

Multimodal approaches using Raman imaging to characterize microplastics and nanoplastics in cells and organisms

Condensed matter physics, chemistry & nanosciences Life Sciences Molecular biophysics Radiation-matter interactions

Abstract

Pollution by microplastics presents ecological risks due to their slow degradation, long-range transport and accumulation in organisms. Although numerous studies have reported their presence in various environments, the degradation of microplastics into nanoplastics and their impact are less well known. Micro/nanoplastics can cross biological barriers and end up in animals and human organs, raising questions about their size, fate and toxicity. This thesis aims to characterize micro/nanoplastics in biological media using Raman imaging and multimodal approaches.

Two biological models will be studied: the biodegradation of microplastics in bacterial biofilms and their biodistribution in zebrafish larvae. The project is part of the ANR Mentalist program, using zebrafish expertise in Raman microscopy, toxicology, microbiology and imaging to analyze and measure microplastic toxicity in vivo.

Laboratory

Institut rayonnement et matière de Saclay
Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie
Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire
Université de Paris
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