About us
Espace utilisateur
INSTN offers more than 40 diplomas from operator level to post-graduate degree level. 30% of our students are international students.
Professionnal development
Professionnal development
Find a training course
INSTN delivers off-the-self or tailor-made training courses to support the operational excellence of your talents.
Human capital solutions
At INSTN, we are committed to providing our partners with the best human capital solutions to develop and deliver safe & sustainable projects.
Home   /   Thesis   /   Therapeutical lipidic nanoassemblies in a biomimetic medium: transformation, fate and interactions

Therapeutical lipidic nanoassemblies in a biomimetic medium: transformation, fate and interactions


Giving a general view of the colloidal stability of nanoparticles in a biological environment remains difficult. This comes mainly from the complexity of biological environments and the diversity of nanoparticles in terms of size distribution, shape, nature of external surface and nanostructure. In particular, the number of physico-chemical studies on “soft” organic particles obtained by self-assembly of bioconjugates remains low. To understand how the physico-chemical characteristics of "soft" nanoparticles direct their interactions with blood proteins, we propose, in collaboration with the Institut Galien, to study a concrete case where the nanostructure and the surface charge of the nanoparticles give different pharmacologically efficiency (analgesic). The objective is to study in detail how nanoparticles formed by self-assembly of bioconjugates interact with a model biological medium, taking into account both the main components (albumin, hemoglobin and lipoproteins) and the hydrodynamic flow from the circulation blood.


Institut rayonnement et matière de Saclay
Service Nanosciences et Innovation pour les Materiaux, la Biomédecine et l’Energie
Laboratoire Interdisciplinaire sur l’Organisation Nanométrique et Supramoléculaire
Top envelopegraduation-hatlicensebookuserusersmap-markercalendar-fullbubblecrossmenuarrow-down