Most studies in anti-infectious immunity focus on characterizing pathogen-specific immune responses and identifying strategies to optimize them. It is now essential to consider interindividual variability related to age, sex, metabolic status, and infectious history, which strongly influence these responses.
IDMIT’s expertise in preclinical modeling of viral infections provides an ideal framework to address these questions. Cytomegalovirus (CMV) infection represents a relevant model due to its high prevalence, its age-dependent effects, and its association with immune aging. Although epidemiological data suggest that CMV seroprevalence impacts responses to other infections and to vaccination, the underlying mechanisms remain poorly understood. We hypothesize heterogeneous effects related to the diversity of host–virus interactions across sites of viral persistence.
This project aims to characterize CMV-specific immune responses in blood and tissues of young and aged non-human primates, and in the context of chronic SIV infection. The objectives are (i) to assess age-related differences in viral dissemination and immune responses, (ii) to evaluate the predictive value of blood markers relative to tissue parameters, and (iii) to study the reciprocal modulation of CMV and SIV responses during co-infection.
These studies will contribute to the development of vaccination strategies targeting the deleterious effects of CMV and the tissue-specific modulation of immune responses.