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Thesis
Home   /   Thesis   /   Development of a dosimetry system to track alpha particles in in vitro assays for Targeted Alpha Therapy

Development of a dosimetry system to track alpha particles in in vitro assays for Targeted Alpha Therapy

Corpuscular physics and outer space Life Sciences Nuclear physics Radiobiology

Abstract

Targeted Alpha Therapy (TAT) is a promising new method of treating cancer. It uses radioactive substances called alpha-emitting radioisotopes that are injected into the patient's body. These substances specifically target cancer cells, allowing the radiation to be concentrated where it is needed most, close to the tumors. Alpha particles are particularly effective because of their short range and ability to target and destroy cancer cells.
As with any new treatment, TAT must undergo preclinical studies to test its effectiveness and compare it to other existing treatments. Much of this research is done in laboratory, where cancer cells are exposed to these radioactive substances to observe their effects, such as cell survival. However, assessing the effects of alpha particles requires special methods because they behave differently than other types of radiation.
Recently, a method for measuring the radiation dose received by cells in laboratory experiments has been successfully tested. This method uses detecto

Laboratory

Institut de recherche sur les lois fondamentales de l’univers
Département Grand Accélérateur National d’Ions Lourds
Grand Accélérateur National d’Ions Lourds
Caen
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