This postdoctoral research project will examine various methods of producing the medical radioisotope 225Ac. These methods will involve irradiating 226Ra using either a material testing reactor (such as the Jules Horowitz Reactor) or a particle accelerator (such as a cyclotron or a rhodotron). The study will determine the optimal conditions for producing 225Ac, including the type and energy of the incident particles, the target material used, and the corresponding production yields, as well as the quantity of contaminants generated.
The first part of the work will involve modelling the irradiation characteristics in research reactors and particle accelerators. This modelling will be carried out at the Department of Reactor Studies at the IRESNE Institute, at the CEA Cadarache site. Monte Carlo simulations using TRIPOLI4®, GEANT4 and PHITS – developed by the CEA, CERN and JAEA, respectively – will be employed to model the JHR and the particle accelerators.
The second part of the project will be carried out in close collaboration with several CEA laboratories. These laboratories will host the postdoctoral researcher on an ad hoc basis to support them through the subsequent stages of the project.
The CHICADE facility in Cadarache is responsible for designing the targets. The proposed work involves identifying the main steps for manufacturing the targets by electrodeposition, starting with a stock of 226Ra-containing material. If possible, a feasibility study will also be conducted on non-irradiated targets with the same properties (cerium/barium model material).
In collaboration with the DRMP units responsible for modelling the thermomechanical aspects of the targets, the proposed work will also involve conducting a feasibility study on the ion irradiation of a model target at a facility such as JANNuS-Saclay or GANIL.