The project aims to tailor-make based-organic nanocarrier enabling to target antibodies to increase the efficacy of therapy (more particularly mantle cell lymphoma) for clinical applications. Our group has developed a unique delivery system based on lipid nanoparticles for imaging and therapeutic purposes since the last 6 years. Based on this technology, the candidate will:
- optimize the targeting of specific ligands into organic nanoparticles (bioconjugate chemistry)
- optimize the encapsulation of drugs in the immunotargeted nanoparticles
- assess the physico-chemical characterization of all nanoparticles
- evaluate the binding affinity of doped and targeted nanoparticles
Laboratory
Département Microtechnologies pour la Biologie et la Santé (LETI) (inactif)
Service Bio-System on Chip
Laboratoire Fonctionnalisation & Chimie pour les Microsystèmes
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