One of the main goals of modern reactor physics is to perform accurate multi-physics simulations of the behaviour of a nuclear reactor core, with a detailed description of the geometry at the fuel pin level. Multi-physics calculations in nominal conditions imply a coupling between a transport equation solver for the neutron and precursor populations, thermal and thermal-hydraulics solvers for heat transfer, and a Bateman solver for computing the isotopic depletion of the nuclear fuel during a reactor cycle. The purpose of this post-doc is to carry out such a fully-coupled calculation using the PATMOS Monte Carlo neutron-transport mini-app and the C3PO coupling platform, both developed at CEA. The target system is core of the size of a commercial reactor.