Scaling Quantum Processing Units (QPU) to hundreds of Qubits leads to profound changes in the Qubits matrix control: this control will be split between its cryogenic part and its room temperature counterpart outside the cryostat. Multiple constraints coming from the cryostat (thermal or mechanical constraints for example) or coming from Qubits properties (number of Qubits, topology, fidelity, etc…) can affect architectural choices. Examples of these choices include Qubits control (digital/analog), instruction set, measurement storage, operation parallelism or communication between the different accelerator parts for example. This postdoctoral research will focused on defining a mid- (100 to 1,000 Qubits) and long-term (more than 10,000 Qubits) architecture of Qubits control at room temperature by starting from existing QPU middlewares (IBM QISKIT for example) and by taking into account specific constraints of the QPU developed at CEA-Leti using solid-state Qubits.